Cyrene as a bio-based solvent for HATU mediated amide coupling
Wilson, Kirsty L. and Murray, Jane and Jamieson, Craig and Watson, Allan J. B. (2018) Cyrene as a bio-based solvent for HATU mediated amide coupling. Organic and Biomolecular Chemistry (16). pp. 2851-2854. ISSN 1477-0520
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Abstract
Amide bonds are one of the underpinning linkages in all living systems and are fundamental within drug discovery. Current methods towards their synthesis frequently rely on the use of dipolar aprotic solvents; however, due to increasingly stringent regulations and growing societal pressures, safe and more sustainable alternatives are highly sought after. Herein, we evaluate the application of the bio-based solvent Cyrene™ in the HATU mediated synthesis of amides and peptides. We found that Cyrene functioned as a competent replacement for DMF in the synthesis of a series of lead-like compounds and dipeptides (25 examples, 63–100%).
Creators(s): |
Wilson, Kirsty L. ![]() ![]() | Item type: | Article |
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ID code: | 65939 |
Keywords: | amide bonds, drug discovery, cyrene, biomolecular chemistry, Chemistry, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 01 Nov 2018 10:18 |
Last modified: | 01 Jan 2021 05:54 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/65939 |
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