Explosivity : an unusual challenge in drug development
Westwood, N. and Londesbrough, D. and Ford, S. J. and Halbert, G. W. (2016) Explosivity : an unusual challenge in drug development. In: 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2016-04-04 - 2016-04-07, SECC.
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Abstract
There remains an urgent global need for new drugs to combat diseases such as malaria, tuberculosis and cancer, as well as overcoming increasing antibiotic resistance. Chemists are moving into ‘new chemical space’ for drug design (1,2) and with this comes the possibility of traditional (and stable) ‘carbon-carbon’ bond structures being replaced by more ‘exotic’ bonding arrangements. While the implication of this on pharmaceutical stability can often be mitigated by suitable formulation and storage strategies, we came across an unusual case of chemical stability: the possibility that the drug was an explosive! By pushing drug designing into uncharted chemical space it could be argued that the possibility of finding explosive molecules of pharmaceutical interest will increase.
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Item type: Conference or Workshop Item(Poster) ID code: 63606 Dates: DateEvent4 April 2016PublishedSubjects: Medicine > Therapeutics. Pharmacology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 04 Apr 2018 11:48 Last modified: 17 Sep 2024 00:24 URI: https://strathprints.strath.ac.uk/id/eprint/63606