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A multicomponent route to functionalized amides and oxazolidinones

McPherson, Christopher G. and Cooper, Alasdair K. and Bubliauskas, Andrius and Mulrainey, Paul and Jamieson, Craig and Watson, Allan J. B. (2017) A multicomponent route to functionalized amides and oxazolidinones. Organic Letters. ISSN 1523-7060

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Abstract

An organobase-mediated, multicomponent reaction of unactivated esters, epoxides, and amines is reported, furnishing functionalized amide derivatives. A wide range of substrates are tolerated under the reaction conditions, including chiral epoxides, which react with no erosion of enantiopurity. Facile modification of the method, through replacing the ester derivative with dimethyl carbonate, enables access to the corresponding oxazolidinone derivatives.