A multicomponent route to functionalized amides and oxazolidinones

Tools

McPherson, Christopher G. and Cooper, Alasdair K. and Bubliauskas, Andrius and Mulrainey, Paul and Jamieson, Craig and Watson, Allan J. B. (2017) A multicomponent route to functionalized amides and oxazolidinones. Organic Letters. ISSN 1523-7060 (https://doi.org/10.1021/acs.orglett.7b03470)

[thumbnail of McPherson-etal-OL2017-A-multicomponent-route-to-functionalized-amides-and-oxazolidinones]
Preview
 Text. Filename: McPherson_etal_OL2017_A_multicomponent_route_to_functionalized_amides_and_oxazolidinones.pdf
Accepted Author Manuscript
Download (812kB)| Preview

Abstract

An organobase-mediated, multicomponent reaction of unactivated esters, epoxides, and amines is reported, furnishing functionalized amide derivatives. A wide range of substrates are tolerated under the reaction conditions, including chiral epoxides, which react with no erosion of enantiopurity. Facile modification of the method, through replacing the ester derivative with dimethyl carbonate, enables access to the corresponding oxazolidinone derivatives.

ORCID iDs

McPherson, Christopher G. ORCID logoORCID: https://orcid.org/0000-0002-3082-0515, Cooper, Alasdair K., Bubliauskas, Andrius, Mulrainey, Paul, Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272 and Watson, Allan J. B.;
  • Item type:Article
    ID code:62573
    Dates:
    Date
    Event
    1 December 2017
    Published
    1 December 2017
    Accepted
    Notes:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.7b03470.
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Strategic Research Themes > Health and Wellbeing
    Depositing user: Pure Administrator
    Date deposited:08 Dec 2017 11:08
    Last modified:17 Dec 2024 09:20
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/62573
CORE (COnnecting REpositories)