Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Hlaka, Lerato and Rosslee, Michael-Jon and Ozturk, Mumin and Kumar, Santosh and Parihar, Suraj and Brombacher, Frank and Khalaf, Abedawn and Carter, Katharine and Scott, Fraser and Suckling, Colin and Guler, Reto (2017) Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. Journal of Antimicrobial Chemotherapy, 72 (12). 3334–3341. ISSN 0305-7453 (https://doi.org/10.1093/jac/dkx326)

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Abstract

The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection have led to a compelling need for evaluation of more effective drug therapies against tuberculosis. New classes of drugs are constantly being evaluated for anti-mycobacterial activity with currently a very limited number of new drugs approved for TB treatment. Minor Groove Binders (MGBs) have previously revealed promising anti-microbial activity against various infectious agents; however have not yet been screened against Mtb.

ORCID iDs

Hlaka, Lerato, Rosslee, Michael-Jon, Ozturk, Mumin, Kumar, Santosh, Parihar, Suraj, Brombacher, Frank, Khalaf, Abedawn ORCID logoORCID: https://orcid.org/0000-0001-9162-7527, Carter, Katharine, Scott, Fraser ORCID logoORCID: https://orcid.org/0000-0003-0229-3698, Suckling, Colin and Guler, Reto;
  • Item type:Article
    ID code:61703
    Dates:
    Date
    Event
    1 December 2017
    Published
    18 September 2017
    Published Online
    5 August 2017
    Accepted
    Notes:This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The version of record Hlaka, L., Rosslee, M-J., Ozturk, M., Kumar, S., Parihar, S., Brombacher, F., ... Guler, R. (2017). Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. Journal of Antimicrobial Chemotherapy, 72(12), 3334–3341, is available online at: https://doi.org/10.1093/jac/dkx326.
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:04 Sep 2017 15:32
    Last modified:11 Nov 2024 11:46
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/61703
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