Advances in biofunctional SERS-active nanoparticles for future clinical diagnostics and therapeutics

Asiala, Steven and Barrett, Lee and Mabbott, Samuel and Graham, Duncan; Ozaki, Yukihiro and Schatz, George C. and Graham, Duncan and Itoh, Tamitake, eds. (2016) Advances in biofunctional SERS-active nanoparticles for future clinical diagnostics and therapeutics. In: Frontiers of Plasmon Enhanced Spectroscopy. ACS Symposium Series, 1 . American Chemical Society, Washington, DC, pp. 131-161. ISBN 9780841232013

Abstract

The synergy afforded by the combination of biofunctionalised nanoparticles and surface enhanced Raman scattering (SERS) has expanded the analytical toolbox for clinical diagnostics and therapeutics. Since their inception, SERS-active nanoparticles have been developed into biofunctional nanoparticles (BFNPs) using a variety of methods to attach biomolecules and pacification layers to nanoparticles to enable detection of various diseases or cancers in vitro and in vivo. However, while there are many reports of the use of BFNPs for diagnostic or therapeutic applications, very few are implemented in a “real” clinical setting, for example, detection of disease biomarkers in tissue or the delivery of drugs to affected cells. This review covers recent advances made in the development of BFNPs for SERS-based detection of clinical samples using in vitro and in vivo methods.

ORCID iDs

Asiala, Steven ORCID: https://orcid.org/0000-0002-3517-9915

Barrett, Lee ORCID: https://orcid.org/0000-0002-5289-657X

Mabbott, Samuel ORCID: https://orcid.org/0000-0003-4926-5467

Graham, Duncan ORCID: https://orcid.org/0000-0002-6079-2105

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• Item metadata

  Item type:	Book Section
  ID code:	60405
  Dates:	Date Event 20 December 2016 Published
  Keywords:	nanoparticles, biofunctionalised, synergy, surface enhanced Raman scattering, biofunctional nanoparticles, SERS-based detection, in-vitro, in-vivo, clinical diagnostics, therapeutics, Chemistry, Chemistry(all)
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Bionanotechnology
  Depositing user:	Pure Administrator
  Date deposited:	05 Apr 2017 11:45
  Last modified:	04 Jun 2021 03:11
  URI:	https://strathprints.strath.ac.uk/id/eprint/60405