Advances in biofunctional SERS-active nanoparticles for future clinical diagnostics and therapeutics

Asiala, Steven and Barrett, Lee and Mabbott, Samuel and Graham, Duncan; Ozaki, Yukihiro and Schatz, George C. and Graham, Duncan and Itoh, Tamitake, eds. (2016) Advances in biofunctional SERS-active nanoparticles for future clinical diagnostics and therapeutics. In: Frontiers of Plasmon Enhanced Spectroscopy. ACS Symposium Series, 1 . American Chemical Society, Washington, DC, pp. 131-161. ISBN 9780841232013

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Abstract

The synergy afforded by the combination of biofunctionalised nanoparticles and surface enhanced Raman scattering (SERS) has expanded the analytical toolbox for clinical diagnostics and therapeutics. Since their inception, SERS-active nanoparticles have been developed into biofunctional nanoparticles (BFNPs) using a variety of methods to attach biomolecules and pacification layers to nanoparticles to enable detection of various diseases or cancers in vitro and in vivo. However, while there are many reports of the use of BFNPs for diagnostic or therapeutic applications, very few are implemented in a “real” clinical setting, for example, detection of disease biomarkers in tissue or the delivery of drugs to affected cells. This review covers recent advances made in the development of BFNPs for SERS-based detection of clinical samples using in vitro and in vivo methods.

ORCID iDs

Asiala, Steven ORCID logoORCID: https://orcid.org/0000-0002-3517-9915, Barrett, Lee ORCID logoORCID: https://orcid.org/0000-0002-5289-657X, Mabbott, Samuel ORCID logoORCID: https://orcid.org/0000-0003-4926-5467 and Graham, Duncan ORCID logoORCID: https://orcid.org/0000-0002-6079-2105; Ozaki, Yukihiro, Schatz, George C., Graham, Duncan and Itoh, Tamitake
  • Item type:Book Section
    ID code:60405
    Dates:
    Date
    Event
    20 December 2016
    Published
    Keywords:nanoparticles, biofunctionalised, synergy, surface enhanced Raman scattering, biofunctional nanoparticles, SERS-based detection, in-vitro, in-vivo, clinical diagnostics, therapeutics, Chemistry, Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Technology and Innovation Centre > Bionanotechnology
    Depositing user: Pure Administrator
    Date deposited:05 Apr 2017 11:45
    Last modified:04 Jun 2021 03:11
    URI:https://strathprints.strath.ac.uk/id/eprint/60405
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