Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering

Heydari, Esmaeil and Mabbott, Samuel and Thompson, David and Graham, Duncan and Cooper, Jonathan M. and Clark, Alasdair W.; Cartwright, Alexander N. and Nicolau, Dan V., eds. (2016) Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering. In: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII. Proceedings of Spie, 9721 . SPIE, USA. ISBN 9781628419559 (https://doi.org/10.1117/12.2209108)

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Abstract

We report a novel nanophotonic biosensor surface capable of both colorimetric detection and Raman-scattered detection of DNA infection markers at extreme sensitivities. Combining direct-write lithography, dip-pen nanolithography based DNA patterning, and molecular self-assembly, we create molecularly-active plasmonic nanostructures onto which metallic nanoparticles are located via DNA-hybridization. Arraying these structures enables optical surfaces that change state when contacted by specific DNA sequences; shifting the surface color while simultaneously generating strong Raman-scattering signals. Patterning the DNA markers onto the plasmonic surface as micro-scale symbols results in easily identifiable color shifts, making this technique applicable to multiplexed lab-on-a-chip and point-of-care diagnostic applications.

ORCID iDs

Heydari, Esmaeil, Mabbott, Samuel ORCID logoORCID: https://orcid.org/0000-0003-4926-5467, Thompson, David, Graham, Duncan ORCID logoORCID: https://orcid.org/0000-0002-6079-2105, Cooper, Jonathan M. and Clark, Alasdair W.; Cartwright, Alexander N. and Nicolau, Dan V.
  • Item type:Book Section
    ID code:57998
    Dates:
    Date
    Event
    2016
    Published
    12 October 2015
    Accepted
    Notes:Heydari, Esmaeil; Mabbott, Samuel; Thompson, David; Graham, Duncan; Cooper, Jonathan M.; Clark, Alasdair W. "Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering." Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII. ed. / Alexander N. Cartwright; Dan V. Nicolau. Proceedings of Spie Vol. 9721 Bellingham WA : SPIE, 2016. 972105, 2016. Copyright 2016 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.2209108
    Subjects:Science > Physics > Optics. Light
    Technology > Engineering (General). Civil engineering (General) > Bioengineering
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:30 Sep 2016 13:47
    Last modified:24 Nov 2024 01:32
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/57998
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