Liquid-filled hard gelatin capsules : excipient/capsule compatibility studies

Kreiner, M. and Thayne, N. and Harkins, D. and Rae, K. and Halbert, G. W. (2016) Liquid-filled hard gelatin capsules : excipient/capsule compatibility studies. In: 7th APS International PharmSci Conference, 2016-09-05 - 2016-09-07, University of Strathclyde.

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    Abstract

    Encapsulation of pharmaceutical formulations as liquids or semisolids, within hard gelatin capsules, presents an important oral dosage strategy for poorly water-soluble drugs, resulting in good bioavailability and reproducible drug absorption. In addition, this technology offers an inherently safer process than powder filled capsules and tablets for highly potent or cytotoxic drugs by avoiding dust generation. Here we present a compatibility study of hard gelatin capsules with common excipients in absence of active pharmaceutical.