Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties

Martinez-Marcos, Laura and Lamprou, Dimitrios and Halbert, Gavin (2016) Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties. In: PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology, 2016-04-04 - 2016-04-07, SECC.

[thumbnail of Martinez-Marcos-etal-WMPBPT-2016-Hot-melt-extrusion-HME-formulations-of-albendazole-for-increasing]
Preview
Text. Filename: Martinez_Marcos_etal_WMPBPT_2016_Hot_melt_extrusion_HME_formulations_of_albendazole_for_increasing.pdf
Accepted Author Manuscript

Download (201kB)| Preview

Abstract

Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).