Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties

Martinez-Marcos, Laura and Lamprou, Dimitrios and Halbert, Gavin (2016) Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties. In: PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology, 2016-04-04 - 2016-04-07, SECC.

[img]
Preview
 Text (Martinez-Marcos-etal-WMPBPT-2016-Hot-melt-extrusion-HME-formulations-of-albendazole-for-increasing)
Martinez_Marcos_etal_WMPBPT_2016_Hot_melt_extrusion_HME_formulations_of_albendazole_for_increasing.pdf
Accepted Author Manuscript
Download (201kB)| Preview

    Abstract

    Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).

    Author(s):Martinez-Marcos, Laura ORCID: https://orcid.org/0000-0001-9701-3083, Lamprou, Dimitrios ORCID: https://orcid.org/0000-0002-8740-1661 and Halbert, Gavin
    Item type:Conference or Workshop Item(Poster)
    ID code:56917
    Keywords:hot-melt extrusion, Albendazole, pharmacurtical manufactures, drug delivery, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all)
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
    Depositing user: Pure Administrator
    Date deposited:11 Jul 2016 11:07
    Last modified:21 Jul 2019 00:38
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/56917
    Export data:
    CORE (COnnecting REpositories)