Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties
Martinez-Marcos, Laura and Lamprou, Dimitrios and Halbert, Gavin (2016) Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties. In: PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology, 2016-04-04 - 2016-04-07, SECC.
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Abstract
Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).
Creators(s): |
Martinez-Marcos, Laura ![]() ![]() | Item type: | Conference or Workshop Item(Poster) |
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ID code: | 56917 |
Keywords: | hot-melt extrusion, Albendazole, pharmacurtical manufactures, drug delivery, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all) |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC) |
Depositing user: | Pure Administrator |
Date deposited: | 11 Jul 2016 11:07 |
Last modified: | 28 Nov 2020 04:11 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/56917 |
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