Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom : 2015/16 mid-season results

Pebody, R and Warburton, F and Ellis, J and Andrews, N and Potts, A and Cottrell, S and Johnston, J and Reynolds, A and Gunson, R and Thompson, C and Galiano, M and Robertson, C and Mullett, D and Gallagher, N and Sinnathamby, M and Yonova, I and Moore, C and McMenamin, J and de Lusignan, S and Zambon, M (2016) Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom : 2015/16 mid-season results. Eurosurveillance, 21 (13). 30179. ISSN 1560-7917 (https://doi.org/10.2807/1560-7917.ES.2016.21.13.30...)

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Abstract

In 2015/16, the influenza season in the United Kingdom was dominated by influenza A(H1N1)pdm09 circulation. Virus characterisation indicated the emergence of genetic clusters, with the majority antigenically similar to the current influenza A(H1N1)pdm09 vaccine strain. Mid-season vaccine effectiveness (VE) estimates show an adjusted VE of 41.5% (95% confidence interval (CI): 3.0–64.7) against influenza-confirmed primary care consultations and of 49.1% (95% CI: 9.3–71.5) against influenza A(H1N1)pdm09. These estimates show levels of protection similar to the 2010/11 season, when this strain was first used in the seasonal vaccine.

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