Effect of oscillatory flow on nucleation kinetics of butyl paraben
Yang, Huaiyu and Yu, Xi and Raval, Vishal and Makkawi, Yassir and Florence, Alastair (2016) Effect of oscillatory flow on nucleation kinetics of butyl paraben. Crystal Growth and Design, 16 (2). pp. 875-886. ISSN 1528-7483 (https://doi.org/10.1021/acs.cgd.5b01437)
Preview |
Text.
Filename: Yang_etal_CGD_2016_Effect_of_oscillatory_flow_on_nucleation_kinetics_of_butyl.pdf
Accepted Author Manuscript License: Unspecified Download (2MB)| Preview |
Abstract
More than 165 induction times of butyl paraben-ethanol solution in a batch moving fluid oscillation baffled crystallizer with various amplitudes (1-9 mm) and frequencies (1.0-9.0 Hz) have been determined to study the effect of COBR operating conditions on nucleation. The induction time decreases with increasing amplitude and frequency at power density below about 500 W/m3; however, a further increase of the frequency and amplitude leads to an increase of the induction time. The interfacial energies and pre-exponential factors in both homogeneous and heterogeneous nucleation are determined by classical nucleation theory at oscillatory frequency 2.0 Hz and amplitudes of 3 or 5 mm both with and without net flow. To capture the shear rate conditions in oscillatory flow crystallizers, a large eddy simulation approach in a computational fluid dynamics framework is applied. Under ideal conditions the shear rate distribution shows spatial and temporal periodicity and radial symmetry. The spatial distributions of the shear rate indicate an increase of average and maximum values of the shear rate with increasing amplitude and frequency. In continuous operation, net flow enhances the shear rate at most time points, promoting nucleation. The mechanism of the shear rate influence on nucleation is discussed.
ORCID iDs
Yang, Huaiyu ORCID: https://orcid.org/0000-0002-3905-436X, Yu, Xi, Raval, Vishal ORCID: https://orcid.org/0000-0002-0620-3525, Makkawi, Yassir and Florence, Alastair ORCID: https://orcid.org/0000-0002-9706-8364;-
-
Item type: Article ID code: 56357 Dates: DateEvent3 February 2016Published28 December 2015Published Online23 December 2015AcceptedNotes: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.cgd.5b01437 Subjects: Science > Chemistry Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)Depositing user: Pure Administrator Date deposited: 12 May 2016 08:39 Last modified: 14 Dec 2024 01:18 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/56357