Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions : C-H activation of unprotected tetrazoles

Kerr, William J. and Lindsay, David M. and Reid, Marc and Atzrodt, Jens and Derdau, Volker and Rojahn, Patrick and Weck, Remo (2016) Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions : C-H activation of unprotected tetrazoles. Chemical Communications, 52 (40). pp. 6669-6672. ISSN 1359-7345

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    Abstract

    The first examples of selective ortho-directed C-H activation with unprotected 2-aryltetrazoles are described. A new base-assisted protocol for iridium (I) hydrogen isotope exchange catalysis allows access to ortho-deuterated and tritiated tetrazoles, including the tetrazole-containing pharmaceutical, Valsartan. Preliminary mechanistic studies are also presented.

    ORCID iDs

    Kerr, William J. ORCID logoORCID: https://orcid.org/0000-0002-1332-785X, Lindsay, David M. ORCID logoORCID: https://orcid.org/0000-0003-4498-5094, Reid, Marc ORCID logoORCID: https://orcid.org/0000-0003-4394-3132, Atzrodt, Jens, Derdau, Volker, Rojahn, Patrick and Weck, Remo;