Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions : C-H activation of unprotected tetrazoles
Kerr, William J. and Lindsay, David and Reid, Marc and Atzrodt, Jens and Derdau, Volker and Rojahn, Patrick and Weck, Remo (2016) Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions : C-H activation of unprotected tetrazoles. Chemical Communications, 52 (40). pp. 6669-6672. ISSN 1359-7345 (https://doi.org/10.1039/C6CC02137A)
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Abstract
The first examples of selective ortho-directed C-H activation with unprotected 2-aryltetrazoles are described. A new base-assisted protocol for iridium (I) hydrogen isotope exchange catalysis allows access to ortho-deuterated and tritiated tetrazoles, including the tetrazole-containing pharmaceutical, Valsartan. Preliminary mechanistic studies are also presented.
ORCID iDs
Kerr, William J. ORCID: https://orcid.org/0000-0002-1332-785X, Lindsay, David ORCID: https://orcid.org/0000-0003-4498-5094, Reid, Marc ORCID: https://orcid.org/0000-0003-4394-3132, Atzrodt, Jens, Derdau, Volker, Rojahn, Patrick and Weck, Remo;-
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Item type: Article ID code: 56205 Dates: DateEvent20 April 2016Published20 April 2016Published Online20 April 2016AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 21 Apr 2016 08:44 Last modified: 08 Oct 2024 00:16 URI: https://strathprints.strath.ac.uk/id/eprint/56205
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