Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions : C-H activation of unprotected tetrazoles

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Kerr, William J. and Lindsay, David and Reid, Marc and Atzrodt, Jens and Derdau, Volker and Rojahn, Patrick and Weck, Remo (2016) Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions : C-H activation of unprotected tetrazoles. Chemical Communications, 52 (40). pp. 6669-6672. ISSN 1359-7345 (https://doi.org/10.1039/C6CC02137A)

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Abstract

The first examples of selective ortho-directed C-H activation with unprotected 2-aryltetrazoles are described. A new base-assisted protocol for iridium (I) hydrogen isotope exchange catalysis allows access to ortho-deuterated and tritiated tetrazoles, including the tetrazole-containing pharmaceutical, Valsartan. Preliminary mechanistic studies are also presented.

ORCID iDs

Kerr, William J. ORCID logoORCID: https://orcid.org/0000-0002-1332-785X, Lindsay, David ORCID logoORCID: https://orcid.org/0000-0003-4498-5094, Reid, Marc ORCID logoORCID: https://orcid.org/0000-0003-4394-3132, Atzrodt, Jens, Derdau, Volker, Rojahn, Patrick and Weck, Remo;
  • Item type:Article
    ID code:56205
    Dates:
    Date
    Event
    20 April 2016
    Published
    20 April 2016
    Published Online
    20 April 2016
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:21 Apr 2016 08:44
    Last modified:16 Dec 2024 21:12
    URI:https://strathprints.strath.ac.uk/id/eprint/56205
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