Anti-infective activities of secondary metabolites from Vitex pinnata
Kamal, Nurkhalida and Clements, Carol and Gray, Alexander I. and Edrada-Ebel, RuAngelie (2016) Anti-infective activities of secondary metabolites from Vitex pinnata. Journal of Applied Pharmaceutical Science, 6 (1). pp. 102-106. ISSN 2231-3354
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Abstract
The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids ß-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4'-trimethoxyflavone (2), 5-hydroxy-7,4'-dimethoxy-flavone (3) and 5-hydroxy-3,3',4',7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1-4 showed moderate antitrypanosomal activity with MIC values of 6.25μg/ml, 19.0, 21.0 and 17.0μM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.
Creators(s): | Kamal, Nurkhalida, Clements, Carol, Gray, Alexander I. and Edrada-Ebel, RuAngelie; | Item type: | Article |
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ID code: | 55711 |
Keywords: | anti-mycobacterial activity, antitrypanosomal activity, flavones, steroids, Vitex pinnata, Therapeutics. Pharmacology, Pharmacology, Toxicology and Pharmaceutics(all), Medicine (miscellaneous), Pharmacology (medical) |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde > University of Strathclyde |
Depositing user: | Pure Administrator |
Date deposited: | 26 Feb 2016 14:52 |
Last modified: | 20 Jan 2021 23:56 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/55711 |
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