Relation between breast cancer and high glycemic index or glycemic load : a meta-analysis of prospective cohort studies

Mullie, Patrick and Koechlin, Alice and Boniol, Mathieu and Autier, Philippe and Boyle, Peter (2016) Relation between breast cancer and high glycemic index or glycemic load : a meta-analysis of prospective cohort studies. Critical Reviews in Food Science and Nutrition, 56 (1). pp. 152-159. ISSN 1040-8398

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    Abstract

    Breast cancer is the commonest form of cancer in women worldwide. It has been suggested that chronic hyperinsulinemia associated with insulin resistance plays a role in breast cancer etiology. To test the hyperinsulinemia hypothesis, a dietary pattern associated with a high glycemic index and glycemic load, both proxies for chronic hyperinsulinemia, should be associated with an increased risk of breast cancer. A meta-analysis restricted to prospective cohort studies was undertaken using a random effects model with tests for statistical significance, publication bias and heterogeneity. The metric for analysis was the risk of breast cancer in the highest relative to the lowest glycemic index and glycemic load dietary pattern. A dietary pattern with a high glycemic index was associated with a summary relative risk (SRR) of 1.05 (95% CI: 1.00, 1.11), and a high glycemic load with a SRR of 1.06 (95% CI: 1.00, 1.13). Adjustments for body mass index [BMI], physical activity and other lifestyle factors did not influence the SRR, nor did menopausal status and estrogen receptor status of the tumor. In conclusion, the current evidence supports a modest association between a dietary pattern with high glycemic index or glycemic load and the risk of breast cancer.

    Author(s):Mullie, Patrick, Koechlin, Alice ORCID: https://orcid.org/0000-0002-0966-5186, Boniol, Mathieu ORCID: https://orcid.org/0000-0001-6585-4443, Autier, Philippe ORCID: https://orcid.org/0000-0003-1533-5412 and Boyle, Peter ORCID: https://orcid.org/0000-0001-6819-3070
    Item type:Article
    ID code:55369
    Notes:This is an Accepted Manuscript of an article published by Taylor & Francis in Critical Reviews in Food Science and Nutrition on 06/03/2015, available online: http://wwww.tandfonline.com/10.1080/10408398.2012.718723.
    Keywords:hyperinsulinemia, nutritional epidemiology, prevention, Pharmacy and materia medica, Neoplasms. Tumors. Oncology (including Cancer), Food Science, Industrial and Manufacturing Engineering, Pharmacology, Toxicology and Pharmaceutics(all)
    Subjects:Medicine > Pharmacy and materia medica
    Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
    Department:Faculty of Science > Mathematics and Statistics
    Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:25 Jan 2016 15:19
    Last modified:19 Jul 2019 02:51
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/55369
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