Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases

Kerr, William J. and Lindsay, David M. and Patel, Vipulkumar K. and Rajamanickam, Muralikrishnan (2015) Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases. Organic and Biomolecular Chemistry, 13 (40). pp. 10131-10135. ISSN 1477-0520

[thumbnail of Kerr-etal-OBC-2015-Efficient-methods-for-enol-phosphate-synthesis-using-carbon-centred]
Preview
Text (Kerr-etal-OBC-2015-Efficient-methods-for-enol-phosphate-synthesis-using-carbon-centred)
Kerr_etal_OBC_2015_Efficient_methods_for_enol_phosphate_synthesis_using_carbon_centred.pdf
Accepted Author Manuscript

Download (3MB)| Preview
    [thumbnail of Kerr-etal-OBC-2015-Efficient-methods-for-enol-phosphate-synthesis-using-carbon]
    Preview
    Text (Kerr-etal-OBC-2015-Efficient-methods-for-enol-phosphate-synthesis-using-carbon)
    Kerr_etal_OBC_2015_Efficient_methods_for_enol_phosphate_synthesis_using_carbon.pdf
    Final Published Version
    License: Creative Commons Attribution 4.0 logo

    Download (232kB)| Preview

      Abstract

      Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.

      ORCID iDs

      Kerr, William J. ORCID logoORCID: https://orcid.org/0000-0002-1332-785X, Lindsay, David M. ORCID logoORCID: https://orcid.org/0000-0003-4498-5094, Patel, Vipulkumar K. and Rajamanickam, Muralikrishnan ORCID logoORCID: https://orcid.org/0000-0001-9836-5478;