Picture of DNA strand

Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

Explore the Open Access research of the Department of Pure & Applied Chemistry. Or explore all of Strathclyde's Open Access research...

Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases

Kerr, William J. and Lindsay, David M. and Patel, Vipulkumar K. and Rajamanickam, Muralikrishnan (2015) Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases. Organic and Biomolecular Chemistry, 13 (40). pp. 10131-10135. ISSN 1477-0520

[img]
Preview
Text (Kerr-etal-OBC-2015-Efficient-methods-for-enol-phosphate-synthesis-using-carbon-centred)
Kerr_etal_OBC_2015_Efficient_methods_for_enol_phosphate_synthesis_using_carbon_centred.pdf
Accepted Author Manuscript

Download (3MB) | Preview
[img]
Preview
Text (Kerr-etal-OBC-2015-Efficient-methods-for-enol-phosphate-synthesis-using-carbon)
Kerr_etal_OBC_2015_Efficient_methods_for_enol_phosphate_synthesis_using_carbon.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo

Download (232kB) | Preview

Abstract

Efficient conversion of ketones into kinetic enol phosphates under mild and accessible conditions has been realised using the developed methods with di-tert-butylmagnesium and bismesitylmagnesium. Optimisation of the quench protocol resulted in high yields of enol phosphates from a range of cyclohexanones and aryl methyl ketones, with tolerance of a range of additional functional units.