Hypertension linked to PDE3A activation

Houslay, Miles (2015) Hypertension linked to PDE3A activation. Nature Genetics, 47 (6). pp. 562-563. ISSN 1061-4036

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Abstract

A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

ORCID iDs

Houslay, Miles ORCID logoORCID: https://orcid.org/0000-0002-3826-8091;