Hypertension linked to PDE3A activation

Houslay, Miles (2015) Hypertension linked to PDE3A activation. Nature Genetics, 47 (6). pp. 562-563. ISSN 1061-4036 (https://doi.org/10.1038/ng.3316)

Abstract

A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

ORCID iDs

Houslay, Miles ORCID: https://orcid.org/0000-0002-3826-8091

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• Item metadata

  Item type:	Article
  ID code:	54110
  Dates:	Date Event June 2015 Published 27 May 2015 Published Online
  Subjects:	Science > Natural history > Genetics Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	31 Aug 2015 08:14
  Last modified:	01 Feb 2025 06:30
  URI:	https://strathprints.strath.ac.uk/id/eprint/54110