Co-Cr wear particles and cobalt ions stimulate the expression of human general toxicology related genes on monocyte like U937 cells

Posada Estefan, Olga Maria and Tate, Rothwelle and Grant, Mary (2013) Co-Cr wear particles and cobalt ions stimulate the expression of human general toxicology related genes on monocyte like U937 cells. In: British Toxicology Society Meeting, 2013-04-07 - 2013-04-10.

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Abstract

Cobalt-chromium (Co-Cr) particles in the nanometre size range are produced by wear at the articulating surfaces of metal-on-metal implants, and are associated with inflammation, bone loss and implant loosening.