The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method

Stones, G. and Argouarch, G. and Kennedy, A.R. and Sherrington, D.C. and Gibson, C.L. (2003) The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method. Organic and Biomolecular Chemistry, 1 (13). pp. 2357-2363. ISSN 1477-0520

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Official URL: http://dx.doi.org/10.1039/b302887a

Abstract

Using L-valine methyl ester hydrochloride as starting material, the synthesis of ( 2S)- 2- isopropyl- 1,4,7- trimethyl-1,4,7- triazacyclononane is described. Various standard Richman - Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.

Creators(s):	Stones, G., Argouarch, G., Kennedy, A.R. ORCID: https://orcid.org/0000-0003-3652-6015, Sherrington, D.C. and Gibson, C.L. ORCID: https://orcid.org/0000-0003-4948-1266;
Item type:	Article
ID code:	505
Keywords:	HIGHLY SELECTIVE EPOXIDATION, MANGANESE COMPLEXES, OLEFIN EPOXIDATION, CHIRAL AZIRIDINES, LIGANDS, TRIAZACYCLONONANE, OXIDATION, CATALYSTS, H2O2, ACID, Chemistry, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry
Subjects:	Science > Chemistry
Department:	Faculty of Science > Pure and Applied Chemistry
Depositing user:	Mr Derek Boyle
Date deposited:	09 Mar 2006
Last modified:	01 Jan 2021 08:06
Related URLs:	http://www.rsc.org/Publishing/Journals/O...
URI:	https://strathprints.strath.ac.uk/id/eprint/505
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