The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method

Stones, G. and Argouarch, G. and Kennedy, A.R. and Sherrington, D.C. and Gibson, C.L. (2003) The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method. Organic and Biomolecular Chemistry, 1 (13). pp. 2357-2363. ISSN 1477-0520 (http://dx.doi.org/10.1039/b302887a)

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Abstract

Using L-valine methyl ester hydrochloride as starting material, the synthesis of ( 2S)- 2- isopropyl- 1,4,7- trimethyl-1,4,7- triazacyclononane is described. Various standard Richman - Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.

ORCID iDs

Stones, G., Argouarch, G., Kennedy, A.R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, Sherrington, D.C. and Gibson, C.L. ORCID logoORCID: https://orcid.org/0000-0003-4948-1266;
  • Item type:Article
    ID code:505
    Dates:
    Date
    Event
    22 May 2003
    Published
    Keywords:HIGHLY SELECTIVE EPOXIDATION, MANGANESE COMPLEXES, OLEFIN EPOXIDATION, CHIRAL AZIRIDINES, LIGANDS, TRIAZACYCLONONANE, OXIDATION, CATALYSTS, H2O2, ACID, Chemistry, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Mr Derek Boyle
    Date deposited:09 Mar 2006
    Last modified:07 Dec 2022 02:50
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/505
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