Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists
Kiyoi, Takao and York, Mark and Francis, Stuart and Edwards, Darren and Walker, Glenn and Houghton, Andrea K and Cottney, Jean E and Baker, James and Adam, Julia M (2010) Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists. Bioorganic and Medicinal Chemistry Letters, 20 (16). pp. 4918-4921. ISSN 0960-894X (https://doi.org/10.1016/j.bmcl.2010.06.067)
Full text not available in this repository.Request a copyAbstract
Novel tricyclic indole-3-carboxamides were synthesized as structurally restricted analogs of bicyclic indoles, and found to be potent CB1 cannabinoid receptor agonists. The CB1 agonist activity depended on the absolute configuration of the chiral center of the tricyclic ring. The preferred enantiomer was more potent than the structurally unconstrained lead compound. Structure-activity relationships in the amide side chain of the indole C-3 position were also investigated.
ORCID iDs
Kiyoi, Takao, York, Mark, Francis, Stuart, Edwards, Darren ORCID: https://orcid.org/0000-0001-9544-8569, Walker, Glenn, Houghton, Andrea K, Cottney, Jean E, Baker, James and Adam, Julia M;-
-
Item type: Article ID code: 49476 Dates: DateEvent15 August 2010PublishedSubjects: Medicine > Pharmacy and materia medica
Technology > Chemical technologyDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 01 Oct 2014 15:18 Last modified: 24 Nov 2024 20:45 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/49476