Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists

Cowley, Phillip M and Baker, James and Buchanan, Kirsteen I and Carlyle, Ian and Clark, John K and Clarkson, Thomas R and Deehan, Maureen and Edwards, Darren and Kiyoi, Yasuko and Martin, Iain and Osbourn, Dawn and Walker, Glenn and Ward, Nick and Wishart, Grant (2011) Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists. Bioorganic and Medicinal Chemistry Letters, 21 (7). pp. 2034-2039. ISSN 0960-894X

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Abstract

The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.

Author(s):Cowley, Phillip M, Baker, James, Buchanan, Kirsteen I, Carlyle, Ian, Clark, John K, Clarkson, Thomas R, Deehan, Maureen, Edwards, Darren, Kiyoi, Yasuko, Martin, Iain, Osbourn, Dawn, Walker, Glenn, Ward, Nick and Wishart, Grant
Item type:Article
ID code:49473
Keywords:administration, oral, biological availability, humans, indoles, receptor, Cannabinoid, CB1, structure-activity relationships, Other systems of medicine, Physical and theoretical chemistry, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry
Subjects:Medicine > Other systems of medicine
Science > Chemistry > Physical and theoretical chemistry
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:01 Oct 2014 15:07
Last modified:19 Jun 2019 13:18
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URI:https://strathprints.strath.ac.uk/id/eprint/49473
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