Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists
Cowley, Phillip M and Baker, James and Buchanan, Kirsteen I and Carlyle, Ian and Clark, John K and Clarkson, Thomas R and Deehan, Maureen and Edwards, Darren and Kiyoi, Yasuko and Martin, Iain and Osbourn, Dawn and Walker, Glenn and Ward, Nick and Wishart, Grant (2011) Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists. Bioorganic and Medicinal Chemistry Letters, 21 (7). pp. 2034-2039. ISSN 0960-894X
Full text not available in this repository.Request a copy from the Strathclyde authorAbstract
The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.
Creators(s): |
Cowley, Phillip M, Baker, James, Buchanan, Kirsteen I, Carlyle, Ian, Clark, John K, Clarkson, Thomas R, Deehan, Maureen, Edwards, Darren ![]() | Item type: | Article |
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ID code: | 49473 |
Keywords: | administration, oral, biological availability, humans, indoles, receptor, Cannabinoid, CB1, structure-activity relationships, Other systems of medicine, Physical and theoretical chemistry, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry |
Subjects: | Medicine > Other systems of medicine Science > Chemistry > Physical and theoretical chemistry |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 01 Oct 2014 15:07 |
Last modified: | 20 Jan 2021 21:28 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/49473 |
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