Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists

Cowley, Phillip M and Baker, James and Buchanan, Kirsteen I and Carlyle, Ian and Clark, John K and Clarkson, Thomas R and Deehan, Maureen and Edwards, Darren and Kiyoi, Yasuko and Martin, Iain and Osbourn, Dawn and Walker, Glenn and Ward, Nick and Wishart, Grant (2011) Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists. Bioorganic and Medicinal Chemistry Letters, 21 (7). pp. 2034-2039. ISSN 0960-894X

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Abstract

The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.

Creators(s): Cowley, Phillip M, Baker, James, Buchanan, Kirsteen I, Carlyle, Ian, Clark, John K, Clarkson, Thomas R, Deehan, Maureen, Edwards, Darren ORCID logoORCID: https://orcid.org/0000-0001-9544-8569, Kiyoi, Yasuko, Martin, Iain, Osbourn, Dawn, Walker, Glenn, Ward, Nick and Wishart, Grant;
Item type:Article
ID code:49473
Keywords:administration, oral, biological availability, humans, indoles, receptor, Cannabinoid, CB1, structure-activity relationships, Other systems of medicine, Physical and theoretical chemistry, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry
Subjects:Medicine > Other systems of medicine
Science > Chemistry > Physical and theoretical chemistry
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:01 Oct 2014 15:07
Last modified:20 Jan 2021 21:28
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URI:https://strathprints.strath.ac.uk/id/eprint/49473
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