Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes
Cochrane, A R and Idziak, C and Kerr, William and Mondal, Bhaskar and Paterson, Laura C and Tuttle, Tell and Andersson, S. and Nilsson, G.N. (2014) Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes. Organic and Biomolecular Chemistry, 12 (22). pp. 3598-3603. ISSN 1477-0520 (https://doi.org/10.1039/C4OB00465E)
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Abstract
The use of alternative solvents in the iridium-catalysed hydrogen isotope exchange reaction with developing phosphine/NHC Ir(I) complexes has identified reaction media which are more widely applicable and industrially acceptable than the commonly employed chlorinated solvent, dichloromethane. Deuterium incorporation into a variety of substrates has proceeded to deliver high levels of labelling (and regioselectivity) in the presence of low catalyst loadings and over short reaction times. The preparative outputs have been complemented by DFT studies to explore ligand orientation, as well as solvent and substrate binding energies within the catalyst system.
ORCID iDs
Cochrane, A R, Idziak, C, Kerr, William ORCID: https://orcid.org/0000-0002-1332-785X, Mondal, Bhaskar, Paterson, Laura C, Tuttle, Tell, Andersson, S. and Nilsson, G.N.;-
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Item type: Article ID code: 47506 Dates: DateEvent2014Published10 April 2014Published Online9 April 2014AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 15 Apr 2014 10:11 Last modified: 27 Oct 2024 11:38 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/47506