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Dose-response relationships for Foot and Mouth disease in cattle and sheep

French, N.P. and Kelly, L.A. and Kosmider, R.D. and Clancy, D. (2002) Dose-response relationships for Foot and Mouth disease in cattle and sheep. Infection and Epidemiology, 128. pp. 325-332. ISSN 0950-2688

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Abstract

The relationships between the inhaled dose of foot and mouth disease virus and the outcomes of infection and disease were examined by fitting dose-response models to experimental data. The parameters for both the exponential and beta-poisson models were estimated using maximum likelihood and Bayesian methods. The median probability of infection given a single inhaled TCID50 was estimated to be 0·031 with 95% Bayesian credibility intervals (CI) of 0·018-0·052 for cattle, and 0·045 (CI = 0·024-0·080) for sheep. These estimates were used to construct dose-response curves and uncertainty distributions for use in quantitative risk assessments.