Dose-response relationships for Foot and Mouth disease in cattle and sheep

Tools

French, N.P. and Kelly, L.A. and Kosmider, R.D. and Clancy, D. (2002) Dose-response relationships for Foot and Mouth disease in cattle and sheep. Infection and Epidemiology, 128. pp. 325-332. ISSN 0950-2688 (http://dx.doi.org/10.1017/S0950268801006446)

Full text not available in this repository.Request a copy

Abstract

The relationships between the inhaled dose of foot and mouth disease virus and the outcomes of infection and disease were examined by fitting dose-response models to experimental data. The parameters for both the exponential and beta-poisson models were estimated using maximum likelihood and Bayesian methods. The median probability of infection given a single inhaled TCID50 was estimated to be 0·031 with 95% Bayesian credibility intervals (CI) of 0·018-0·052 for cattle, and 0·045 (CI = 0·024-0·080) for sheep. These estimates were used to construct dose-response curves and uncertainty distributions for use in quantitative risk assessments.

ORCID iDs

French, N.P., Kelly, L.A. ORCID logoORCID: https://orcid.org/0000-0002-2242-0781, Kosmider, R.D. and Clancy, D.;
CORE (COnnecting REpositories)