Development of a sustainable catalytic ester amidation process

Caldwell, Nicola and Jamieson, Craig and Simpson, Iain and Watson, Allan J. B. (2013) Development of a sustainable catalytic ester amidation process. ACS Sustainable Chemistry and Engineering, 1 (10). pp. 1339-1344. (https://doi.org/10.1021/sc400204g)

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Abstract

We describe the development of a sustainable ester amidation process. Base and solvent screening, combined with the application of Design of Experiments methodology was employed to identify an optimized set of reaction conditions using a sustainable protocol. Utilizing these optimized conditions, treatment of a range of ester derivatives with amino alcohols in the presence of a catalytic quantity of potassium phosphate deploying iso-propanol as solvent results in the highly efficient generation of a range of amido-alcohol derivatives in good to excellent yield, accompanied with excellent reaction mass efficiency (RME).

ORCID iDs

Caldwell, Nicola, Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272, Simpson, Iain and Watson, Allan J. B.;
  • Item type:Article
    ID code:45736
    Dates:
    Date
    Event
    7 October 2013
    Published
    30 July 2013
    Published Online
    Notes:This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in ACS Sustainable Chemistry & Engineering, copyright © American Chemical Society after peer review. To access the final edited and published work, see http://pubs.acs.org/doi/abs/10.1021/sc400204g.
    Keywords:sustainable ester amidation, amino alcohol, reaction mass efficiency, potassium phosphate, Chemistry, Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:06 Nov 2013 16:54
    Last modified:23 Sep 2021 04:26
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/45736
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