Development of a sustainable catalytic ester amidation process
Caldwell, Nicola and Jamieson, Craig and Simpson, Iain and Watson, Allan J. B. (2013) Development of a sustainable catalytic ester amidation process. ACS Sustainable Chemistry and Engineering, 1 (10). pp. 1339-1344.
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Abstract
We describe the development of a sustainable ester amidation process. Base and solvent screening, combined with the application of Design of Experiments methodology was employed to identify an optimized set of reaction conditions using a sustainable protocol. Utilizing these optimized conditions, treatment of a range of ester derivatives with amino alcohols in the presence of a catalytic quantity of potassium phosphate deploying iso-propanol as solvent results in the highly efficient generation of a range of amido-alcohol derivatives in good to excellent yield, accompanied with excellent reaction mass efficiency (RME).
Creators(s): |
Caldwell, Nicola, Jamieson, Craig ![]() | Item type: | Article |
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ID code: | 45736 |
Notes: | This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in ACS Sustainable Chemistry & Engineering, copyright © American Chemical Society after peer review. To access the final edited and published work, see http://pubs.acs.org/doi/abs/10.1021/sc400204g. |
Keywords: | sustainable ester amidation, amino alcohol, reaction mass efficiency, potassium phosphate, Chemistry, Chemistry(all) |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 06 Nov 2013 16:54 |
Last modified: | 20 Jan 2021 20:58 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/45736 |
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