Enzyme-responsive polymer hydrogel particles for controlled release

Thornton, Paul D. and Mart, Robert J. and Ulijn, Rein V. (2007) Enzyme-responsive polymer hydrogel particles for controlled release. Advanced Materials, 19 (9). pp. 1252-1256. ISSN 0935-9648

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Abstract

A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).