Enzyme-responsive polymer hydrogel particles for controlled release

Thornton, Paul D. and Mart, Robert J. and Ulijn, Rein V. (2007) Enzyme-responsive polymer hydrogel particles for controlled release. Advanced Materials, 19 (9). pp. 1252-1256. ISSN 0935-9648

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Abstract

A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).

ORCID iDs

Thornton, Paul D., Mart, Robert J. and Ulijn, Rein V. ORCID logoORCID: https://orcid.org/0000-0001-7974-3779;