Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Pyne, Susan and Pyne, Nigel (2013) Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer. Cancer Cell, 23 (1). pp. 5-7. ISSN 1878-3686 (https://doi.org/10.1016/j.ccr.2012.12.005)

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Abstract

In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. This appears critical for progression from chronic inflammation to colon cancer.

ORCID iDs

Pyne, Susan ORCID logoORCID: https://orcid.org/0000-0002-6608-9584 and Pyne, Nigel ORCID logoORCID: https://orcid.org/0000-0002-5657-4578;
CORE (COnnecting REpositories)