Asymmetric rhodium-catalysed addition of arylboronic acids to acyclic unsaturated esters containing a basic γ-amino group

Anderson, Niall A and Fallon, Brendan J and Valverde, Elena and MacDonald, Simon J F and Pritchard, John M and Suckling, Colin and Watson, Allan (2012) Asymmetric rhodium-catalysed addition of arylboronic acids to acyclic unsaturated esters containing a basic γ-amino group. Synlett, 23 (19). pp. 2817-2821. ISSN 0936-5214

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Abstract

Application of the Miyaura–Hayashi rhodium-catalysed addition of aryl boronic acids to acyclic unsaturated esters featuring basic centres to yield γ-amino butyric acids incorporating a substituted β-phenyl group is described. Unoptimised isolated yields and enantiomeric excesses vary from moderate to excellent, and the method tolerates a variety of substitution patterns and a range of functionality.