Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents

MacMillan, Donna Stephanie and Murray, Jane and Sneddon, Helen F. and Jamieson, Craig and Watson, Allan (2012) Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents. Green Chemistry, 14 (11). pp. 3016-3019. ISSN 1463-9262 (https://doi.org/10.1039/C2GC36378J)

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Abstract

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.

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• Item metadata

  Item type:	Article
  ID code:	41364
  Dates:	Date Event 2012 Published 2 October 2012 Published Online
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	09 Oct 2012 10:59
  Last modified:	08 Apr 2024 20:09
  URI:	https://strathprints.strath.ac.uk/id/eprint/41364