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Research activity at Architecture explores a wide variety of significant research areas within architecture and the built environment. Among these is the better exploitation of innovative construction technologies and ICT to optimise 'total building performance', as well as reduce waste and environmental impact. Sustainable architectural and urban design is an important component of this. To this end, the Cluster for Research in Design and Sustainability (CRiDS) focuses its research energies towards developing resilient responses to the social, environmental and economic challenges associated with urbanism and cities, in both the developed and developing world.

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Loss of Gli3 enhances the viability of embryonic telencephalic cells in vitro

Zaki, Paulett A and Martynoga, Ben and Delafield-Butt, J T and Fotaki, V and Yu, T and Price, D J (2005) Loss of Gli3 enhances the viability of embryonic telencephalic cells in vitro. European Journal of Neuroscience, 22 (6). pp. 1547-1551. ISSN 0953-816X

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Abstract

The transcription factor Gli3 is important for brain and limb development. Mice homozygous for a mutation in Gli3 (Gli3(Xt/Xt)) have severe abnormalities of telencephalic development and previous studies have suggested that aberrant cell death may contribute to the Gli3(Xt/Xt) phenotype. We demonstrate that telencephalic cells from embryonic Gli3(Xt/Xt) embryos survive better and are more resistant to death induced by cytosine arabinoside, a nucleoside analogue that induces death in neuronal progenitors and neurons, than are control counterparts in vitro. Culture medium conditioned by Gli3(Xt/Xt) cells is more effective at enhancing the viability of control telencephalic cells than medium conditioned by control cells, indicating that Gli3(Xt/Xt) cells release a factor or factors which enhance telencephalic cell viability. Gli3(Xt/Xt) cells are also more sensitive to released factors present in conditioned media. These data suggest that Gli3 plays both cell-autonomous and cell-nonautonomous roles in mediating telencephalic cell viability.