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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

The interaction of hexavalent chromium with mouse macrophages

Lalaouni, A. and Kupper, C. and Grant, M.H. (2002) The interaction of hexavalent chromium with mouse macrophages. Toxicology, 192 (1). p. 86. ISSN 0300-483X

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Abstract

Many orthopaedic implants are made of stainless steel or cobalt–chrome alloys which degrade in vivo, releasing metal ions and particles into the body. This can lead to loosening of prostheses through local inflammatory processes and toxicity to adjacent tissues. Cr VI is one of the most toxic ions released from metal implants, and concentrations up to 2 mM have been measured in tissues samples adjacent to retrieved implants (Blumenthal et al., 1994). It is well recognised as a carcinogen in man (Langard, 1983) although the mechanism of action is undetermined. In this study Cr VI toxicity to macrophages was assessed in vitro using the J774.1 murine macrophage cell line.