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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Synthesis and neuromuscular blocking activity of 16beta-n-methylpiperazino steroidal derivatives

Jindal, D.P. and Piplani, P. and Fajrak, H. and Prior, C.B. and Marshall, I.G. (2002) Synthesis and neuromuscular blocking activity of 16beta-n-methylpiperazino steroidal derivatives. European Journal of Medicinal Chemistry, 37 (11). pp. 901-908. ISSN 0223-5234

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Abstract

Steroidal quaternary ammonium compounds 12 and 13 with quaternised nitrogen at positions 3 and 16 of the steroidal nucleus in androstane series were synthesised and their neuromuscular blocking activities and ganglion blocking activities were studied using chick biventer and anaesthetised cat as the models. The bisquaternary compounds 12 and 13 have been found to be greater in potency than d-tubocurarine. Acetoxy derivative 13 has been found to be more potent than pipecuronium bromide taking d-tubocurarine as the standard compound indicating the need of acetoxy function at position 16.