Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism

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Zhang, L. and Parratt, J.R. and Beastall, G.H. and Pyne, N.J. and Furman, B.L. (2002) Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism. European Journal of Pharmacology, 435 (2-3). pp. 269-276. ISSN 0014-2999 (https://doi.org/10.1016/S0014-2999(01)01398-X)

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Abstract

We examined the contribution of hypothyroidism to streptozotocin diabetes-induced alterations in the arrhythmia susceptibility of ex vivo hearts to regional zero-flow ischaemia. Diabetic rats received either protamine zinc insulin (10 IU/kg/day, s.c.) or triiodothyronine (10 microg/kg/day, s.c.) for 8 weeks commencing 72 h after injection of streptozotocin (60 mg/kg, i.p.). Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion. Serum free thyroxine concentrations, rectal temperature and ex vivo heart rate were significantly decreased in the 8-week diabetic group.

ORCID iDs

Zhang, L., Parratt, J.R., Beastall, G.H., Pyne, N.J. ORCID logoORCID: https://orcid.org/0000-0002-5657-4578 and Furman, B.L.;
CORE (COnnecting REpositories)