A mild and efficient method for the one-pot monocarboxymethylation of primary amines

Gibbs, Timothy J. K. and Boomhoff, Michael and Tomkinson, Nicholas C. O. (2007) A mild and efficient method for the one-pot monocarboxymethylation of primary amines. Synlett (10). pp. 1573-1576. ISSN 0936-5214 (https://doi.org/10.1055/s-2007-982531)

Abstract

A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield.

ORCID iDs

Tomkinson, Nicholas C. O. ORCID: https://orcid.org/0000-0002-5509-0133

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• Item metadata

  Item type:	Article
  ID code:	34180
  Dates:	Date Event 2007 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	20 Oct 2011 13:50
  Last modified:	11 Nov 2024 09:52
  URI:	https://strathprints.strath.ac.uk/id/eprint/34180