Di-tert-butylmagnesium as an atom-efficient, carbon-centred base reagent for the preparation of silyl enol ethers from ketones

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Kerr, William J. and Watson, Allan J. B. and Hayes, Douglas. (2008) Di-tert-butylmagnesium as an atom-efficient, carbon-centred base reagent for the preparation of silyl enol ethers from ketones. Synlett, 2008 (9). pp. 1386-1390. ISSN 0936-5214 (https://doi.org/10.1055/s-2008-1072739)

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Abstract

Di-tert-butylmagnesium has been found to be a reactive, yet non-nucleophilic and non-reductive, carbon-centred base for the deprotonation of a series of ketones. This reagent demonstrates equally high reactivity when used as either the pre-formed reagent, or in a more accessible one-pot protocol from the parent Grignard reagent, and offers improved atom-efficiency over more traditionally employed bases.

ORCID iDs

Kerr, William J. ORCID logoORCID: https://orcid.org/0000-0002-1332-785X, Watson, Allan J. B. and Hayes, Douglas.;
  • Item type:Article
    ID code:19625
    Dates:
    Date
    Event
    23 May 2008
    Published
    Notes:M1 - Copyright (C) 2011 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2008:781418(Journal)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Strathprints Administrator
    Date deposited:27 May 2010 09:13
    Last modified:11 Nov 2024 09:21
    URI:https://strathprints.strath.ac.uk/id/eprint/19625
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