Release of chromium from orthpaedic arthroplasties

Afolaranmi, G.A. and Tettey, J.N.A. and Meek, R.M.D. and Grant, M.H. (2008) Release of chromium from orthpaedic arthroplasties. Open Orthopaedics Journal, 2 (9). pp. 10-18. ISSN 1874-3250

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Abstract

Many orthopaedic implants are composed of alloys containing chromium. Of particular relevance is the increasing number of Cobalt Chromium bearing arthroplasies being inserted into young patients with osteoarthritis. Such implants will release chromium ions. These patients will be exposed to the released chromium for over 50 years in some cases. The subsequent chromium ion metabolism and redistribution in fluid and tissue compartments is complex. In addition, the potential biological effects of chromium are also controversial, including DNA and chromosomal damage, reduction in CD8 lymphocyte levels and possible hypersensitivity reactions (ALVAL). The establishment of these issues and the measurement of chromium in biological fluids is the subject of this review.

Creators(s): Afolaranmi, G.A., Tettey, J.N.A., Meek, R.M.D. and Grant, M.H. ORCID logoORCID: https://orcid.org/0000-0002-7712-404X;
Item type:Article
ID code:18401
Notes:PMID: PMC2685051
Keywords:chromium, orthpaedic arthroplasties, bioengineering, orthopaedics, Bioengineering, Engineering (General). Civil engineering (General), Physiology
Subjects:Technology > Engineering (General). Civil engineering (General) > Bioengineering
Technology > Engineering (General). Civil engineering (General)
Science > Physiology
Department:Faculty of Engineering > Bioengineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Ms Ashley Urie
Date deposited:26 Mar 2010 15:38
Last modified:25 May 2020 16:02
URI:https://strathprints.strath.ac.uk/id/eprint/18401
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