Picture of boy being examining by doctor at a tuberculosis sanatorium

Understanding our future through Open Access research about our past...

Strathprints makes available scholarly Open Access content by researchers in the Centre for the Social History of Health & Healthcare (CSHHH), based within the School of Humanities, and considered Scotland's leading centre for the history of health and medicine.

Research at CSHHH explores the modern world since 1800 in locations as diverse as the UK, Asia, Africa, North America, and Europe. Areas of specialism include contraception and sexuality; family health and medical services; occupational health and medicine; disability; the history of psychiatry; conflict and warfare; and, drugs, pharmaceuticals and intoxicants.

Explore the Open Access research of the Centre for the Social History of Health and Healthcare. Or explore all of Strathclyde's Open Access research...

Image: Heart of England NHS Foundation Trust. Wellcome Collection - CC-BY.

Multiplexed detection of infectious diseases by SERRS

Faulds, K. and Ricketts, Alastair and McCarney, Karen M. and Smith, W.E. and Graham, D. (2006) Multiplexed detection of infectious diseases by SERRS. Abstracts of papers - American Chemical Society, 231. Anyl 314. ISSN 0065-7727

Full text not available in this repository. Request a copy from the Strathclyde author


Surface enhanced resonance Raman scattering (SERRS) is an analytical technique with several advantages over competitive techniques in terms of improved sensitivity and multiplexing. However, the lack of quantitative data relating to real examples has prevented more widespread adoption of the technique. Here we show multiplexed detection of two infectious diseases using a SERRS based DNA assay. SERRS active DNA probes were used in conjunction with PCR to allow simultaneous detection of Chlamydia and Gonorrhoea from urine. Silver nanoparticles were used to provide the enhancement and an assay compatible with existing instrumentation was created. Two assays have been studied and the data can be obtained in a single tube format and offers the flexibility to add further targets as desired. The technique is more sensitive than corresponding fluorescence detection and quantitative data has been obtained. This study demonstrates how SERRS can be a useful tool for meaningful analysis in molecular diagnostics.