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Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

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Quantitation of biomolecules conjugated to nanoparticles by enzyme hydrolysis

McKenzie, F. and Steven, V. and Ingram, A. and Graham, D. (2009) Quantitation of biomolecules conjugated to nanoparticles by enzyme hydrolysis. Chemical Communications (London) (20). pp. 2872-2874. ISSN 0009-241X

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Abstract

A novel method for quantifying biomolecules immobilised onto gold and silver nanoparticles is reported; fluorescent-labelled antibodies and DNA are hydrolysed on the surface of the nanoparticles by the addition of trypsin and DNase I, respectively, resulting in the release of the quantifiable fluorescent label into the bulk solution.