Synthesis of a benzotriazole azo dye phosphoramidite for labelling of oligonucleotides

Brown, R. and Smith, W.E. and Graham, D. (2003) Synthesis of a benzotriazole azo dye phosphoramidite for labelling of oligonucleotides. Tetrahedron Letters, 44 (7). pp. 1339-1342. ISSN 0040-4039

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Abstract

The synthesis of a benzotriazole azo dye phosphoramidite and the subsequent use in solid phase synthesis of oligonucleotides is reported. The azo dye is shown as a surface enhanced resonance Raman label for oligonucleotides that is capable of immobilisation of the oligonucleotide on metal surfaces such as silver nanoparticles. (C) 2003 Elsevier Science Ltd. All rights reserved.

ORCID iDs

Brown, R., Smith, W.E. and Graham, D. ORCID logoORCID: https://orcid.org/0000-0002-6079-2105;