Reductive cleavage of sulfones and sulfonamides by neutral organic super electron-donor (S.E.D.) reagent

Schoenebeck, Fransziska and Murphy, John A. and Zhou, Sheng-ze and Uenoyama, Yoshitaka and Miclo, Yves and Tuttle, Tell (2007) Reductive cleavage of sulfones and sulfonamides by neutral organic super electron-donor (S.E.D.) reagent. Journal of American Chemical Society, 129 (44). pp. 13368-13369. ISSN 1520-5126 (https://doi.org/10.1021/ja074417h)

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Abstract

The sulfonyl group finds extensive applications in organic and medicinal chemistry both in sulfonamides, popular as robust protecting groups for amines, and in sulfones. Frequently, sulfones are introduced into synthetic schemes to assist particular transformations; further progress along the synthetic route can later require the removal of a sulfone group, and this can be achieved by reductive desulfonylation or, in the special cases of α-halo- or ß-acyloxysulfones, by elimination to an alkene.

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• Item metadata

  Item type:	Article
  ID code:	9949
  Dates:	Date Event 16 October 2007 Published 18 June 2007 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Strathprints Administrator
  Date deposited:	05 Dec 2011 14:44
  Last modified:	22 Dec 2024 01:12
  URI:	https://strathprints.strath.ac.uk/id/eprint/9949