Association between markers of brain pathology and verbal memory binding in autosomal dominant Alzheimer’s disease

Tools

Parra‐Rodriguez, Mario A and Baena, Ana Y and Munera, Diana and Badillo‐Cabrera, Alex L and Félix, Nikole A Bonillas and Lopera, Francisco and Quiroz, Yakeel T. (2024) Association between markers of brain pathology and verbal memory binding in autosomal dominant Alzheimer’s disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 20 (S2). e092260. ISSN 1552-5279 (https://doi.org/10.1002/alz.092260)

[thumbnail of Association-between-markers-of-brain-pathology-and-verbal-memory-binding-in-autosomal-dominant-Alzheimer�s-disease]
Preview
 Text. Filename: Association-between-markers-of-brain-pathology-and-verbal-memory-binding-in-autosomal-dominant-Alzheimer_s-disease.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo
Download (96kB)| Preview

Abstract

Background: There is a need to develop neuropsychological measures to detect Alzheimer’s disease (AD)‐pathology and track cognitive changes along the AD trajectory. We previously showed that memory decline during word list learning (CERAD), associative memory (LAS‐FNAME test), working memory (Visual Short‐Memory Binding Test), and others, are associated with amyloid and tau pathology in members of Colombian families with autosomal dominant AD. Here we sought to determine whether associative verbal memory (Memory Binding Test ‐ MBT, (Buschke, 2014)) is associated with PET in vivo markers of brain pathology and whether it can distinguish those who will develop dementia later in life due to autosomal‐dominant AD from age‐matched non‐carriers. Methods: A total of 33 PSEN1‐E280A carriers (Age=37.6±6.17; 61% females) and 37 non‐carriers (Age=35.1±5.87; 54% females) from the Colombia‐Boston (COLBOS) Biomarker study were included. They were matched according to age and education. All participants completed cognitive testing, florbetapir (amyloid), and flortaucipir (tau) PET imaging. We implemented regression models to investigate the extent to which group membership, cortical amyloid burden, and regional tau pathology accounted for performance on the MBT. Results: Carriers showed poorer performance on the MMSE (p

ORCID iDs

Parra‐Rodriguez, Mario A ORCID logoORCID: https://orcid.org/0000-0002-2412-648X, Baena, Ana Y, Munera, Diana, Badillo‐Cabrera, Alex L, Félix, Nikole A Bonillas, Lopera, Francisco and Quiroz, Yakeel T.;
CORE (COnnecting REpositories)