Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling

Halford-McGuff, John M. and Richardson, Thomas M. and McKay, Aidan P. and Peschke, Frederik and Burley, Glenn A. and Watson, Allan J. B. (2024) Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling. Beilstein Journal of Organic Chemistry, 20. pp. 3198-3204. ISSN 1860-5397 (https://doi.org/10.3762/bjoc.20.265)

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Abstract

We report the synthesis of germanyl triazoles formed via a copper-catalysed azide–alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The installation of the Ge moiety enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species.

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• Item metadata

  Item type:	Article
  ID code:	91549
  Dates:	Date Event 5 December 2024 Published 25 November 2024 Accepted
  Subjects:	Science > Chemistry > Organic chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Bionanotechnology
  Depositing user:	Pure Administrator
  Date deposited:	12 Dec 2024 15:48
  Last modified:	18 Dec 2024 09:24
  Related URLs:	https://doi.org/10.17630/53959471-068e-4...
  URI:	https://strathprints.strath.ac.uk/id/eprint/91549