SLC54 mitochondrial pyruvate carriers in GtoPdb v.2023.1

Tavoulari, Sotiria and Wilson, Calum (2023) SLC54 mitochondrial pyruvate carriers in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). ISSN 2633-1020 (https://doi.org/10.2218/gtopdb/F1006/2023.1)

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Abstract

Pyruvate is oxidized to acetyl‐CoA by pyruvate dehydrogenase which is localized in the mitochondrial matrix. The mitochondrial pyruvate carrier (MPC) is composed of SLC54 family members (MPC1 and MPC2) [1, 5], which form functional hetero-dimers [9, 8]. The MPC is expressed in the inner mitochondrial membrane and involved in the import of pyruvate into mitochondria [1, 5]. Ubiquitous disruption of either MPC1 or MPC2 expression results in embryonic lethality [11, 12]. Clinically relevant concentrations of the insulin sensitizers, thiazolidinediones, inhibit the MPC [3]. Other clinically relevant inhibitors of the MPC complex are lonidamine [7, 8], quinolone antibacterials [6], entacapone and nitrofurantoin [8].

ORCID iDs

Tavoulari, Sotiria and Wilson, Calum ORCID logoORCID: https://orcid.org/0000-0003-2500-0632;
CORE (COnnecting REpositories)