SLC54 mitochondrial pyruvate carriers (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology database

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Wilson, Calum (2020) SLC54 mitochondrial pyruvate carriers (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology database. IUPHAR/BPS Guide to Pharmacology CITE, 2020 (5). ISSN 2633-1020 (https://doi.org/10.2218/gtopdb/F1006/2020.5)

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Abstract

Pyruvate is oxidized to acetyl‐CoA by pyruvate dehydrogenase which is localized in the mitochondrial matrix. The mitochondrial pyruvate carrier (MPC) is a hetero-oligomer composed of SLC54 family members (MPC1 and MPC2). The MPC is expressed in the inner mitochondrial membrane and involved in the import of pyruvate into mitochondria [1, 5]. Ubiquitous disruption of either MPC1 or MPC2 expression results in embryonic lethality [7, 8]. Clinically relevant concentrations of the insulin sensitizers, thiazolidinediones, specifically inhibit the MPC [3].

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Wilson, Calum ORCID logoORCID: https://orcid.org/0000-0003-2500-0632;
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