Rapid assessment of crystal nucleation and growth kinetics : comparison of seeded and unseeded experiments
Cashmore, Andrew and Miller, Russell and Jolliffe, Hikaru and Brown, Cameron J. and Lee, Mei and Haw, Mark D. and Sefcik, Jan (2023) Rapid assessment of crystal nucleation and growth kinetics : comparison of seeded and unseeded experiments. Crystal Growth and Design, 23 (7). pp. 4779-4790. ISSN 1528-7483 (https://doi.org/10.1021/acs.cgd.2c01406)
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Abstract
In this work, we outlined an experimental workflow enabling the rapid assessment of primary and secondary nucleation and crystal growth kinetics. We used small-scale experiments in agitated vials with in situ imaging for crystal counting and sizing to quantify nucleation and growth kinetics of α-glycine in aqueous solutions as a function of supersaturation at isothermal conditions. Seeded experiments were required to assess crystallization kinetics when primary nucleation is too slow, especially at lower supersaturations often encountered in continuous crystallization processes. At higher supersaturations, we compared results from seeded and unseeded experiments and carefully analyzed interdependencies of primary and secondary nucleation and growth kinetics. This approach allows for the rapid estimation of absolute values of primary and secondary nucleation and growth rates without relying on any specific assumptions about functional forms of corresponding rate expressions used for estimation approaches based on fitting population balance models. Quantitative relationships between nucleation and growth rates at given conditions provide useful insights into crystallization behavior and can be explored to rationally manipulate crystallization conditions for achieving desirable outcomes in batch or continuous crystallization processes.
ORCID iDs
Cashmore, Andrew, Miller, Russell, Jolliffe, Hikaru, Brown, Cameron J. ORCID: https://orcid.org/0000-0001-7091-1721, Lee, Mei, Haw, Mark D. ORCID: https://orcid.org/0000-0003-3736-1857 and Sefcik, Jan ORCID: https://orcid.org/0000-0002-7181-5122;-
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Item type: Article ID code: 85706 Dates: DateEvent5 July 2023Published20 June 2023Published Online5 June 2023AcceptedSubjects: Science > Chemistry > Crystallography Department: Faculty of Engineering > Chemical and Process Engineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
Technology and Innovation Centre > Bionanotechnology
Strategic Research Themes > Ocean, Air and SpaceDepositing user: Pure Administrator Date deposited: 07 Jun 2023 10:32 Last modified: 22 Dec 2024 01:33 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/85706