Real-world effectiveness of systemic anticancer therapy for advanced melanoma in the west of Scotland from 2010 to 2018

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Clarke, Julie and Bennie, Marion and Kurdi, Amanj and Pan, Jiafeng and Mueller, Tanja and Crearie, Christine and Baillie, Kelly and Laskey, Jennifer and Waterston, Ashita (2023) Real-world effectiveness of systemic anticancer therapy for advanced melanoma in the west of Scotland from 2010 to 2018. Future Oncology, 19 (6). pp. 451-461. ISSN 1479-6694 (https://doi.org/10.2217/fon-2022-0959)

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Abstract

Aim: Assess the real-world effectiveness of systemic anticancer therapy in advanced (unresectable or metastatic) melanoma. Methods: This was a retrospective cohort study linking routine healthcare data with systemic anticancer therapy prescriptions for patients starting immunotherapy or targeted treatments between 1 November 2010 and 31 December 2017 in the west of Scotland. Results: Among 362 patients identified, median overall survival varied between 18.5 months (95% CI: 14.4-not estimable) for ipilimumab/nivolumab combination and 5.6 months (95% CI: 4.5-7.3) for dabrafenib, but there were differences in the characteristics of each regimen cohort. Raised lactate dehydrogenase levels and Eastern Cooperative Oncology Group performance status =2 negatively impacted overall survival. Conclusion: The patients had a shorter median overall survival than those in pivotal trials. This was expected, given that this real-world cohort included patients with poorer prognostic indicators, typically excluded from trials.

ORCID iDs

Clarke, Julie, Bennie, Marion ORCID logoORCID: https://orcid.org/0000-0002-4046-629X, Kurdi, Amanj ORCID logoORCID: https://orcid.org/0000-0001-5036-1988, Pan, Jiafeng, Mueller, Tanja ORCID logoORCID: https://orcid.org/0000-0002-0418-4789, Crearie, Christine, Baillie, Kelly, Laskey, Jennifer and Waterston, Ashita;
CORE (COnnecting REpositories)