Raman imaging of nanocarriers for drug delivery

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Vanden-Hehir, Sally and Tipping, William J. and Lee, Martin and Brunton, Valerie G. and Williams, Anna and Hulme, Alison N. (2019) Raman imaging of nanocarriers for drug delivery. Nanomaterials, 9 (3). pp. 1-19. 341. ISSN 2079-4991 (https://doi.org/10.3390/nano9030341)

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Abstract

The efficacy of pharmaceutical agents can be greatly improved through nanocarrier delivery. Encapsulation of pharmaceutical agents into a nanocarrier can enhance their bioavailability and biocompatibility, whilst also facilitating targeted drug delivery to specific locations within the body. However, detailed understanding of the in vivo activity of the nanocarrier-drug conjugate is required prior to regulatory approval as a safe and effective treatment strategy. A comprehensive understanding of how nanocarriers travel to, and interact with, the intended target is required in order to optimize the dosing strategy, reduce potential off-target effects, and unwanted toxic effects. Raman spectroscopy has received much interest as a mechanism for label-free, non-invasive imaging of nanocarrier modes of action in vivo. Advanced Raman imaging techniques, including coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS), are paving the way for rigorous evaluation of nanocarrier activity at the single-cell level. This review focuses on the development of Raman imaging techniques to study organic nanocarrier delivery in cells and tissues.

  • Item type:Article
    ID code:84512
    Dates:
    Date
    Event
    3 March 2019
    Published
    19 February 2019
    Accepted
    Notes:Funding Information: Funding: This research was funded by the BBSRC (BB/M010996/1 studentship to SVH; and BB/N021614/1). Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Vanden-Hehir S, Tipping WJ, Lee M, Brunton VG, Williams A, Hulme AN. Raman Imaging of Nanocarriers for Drug Delivery. Nanomaterials. 2019; 9(3):341. https://doi.org/10.3390/nano9030341
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:02 Mar 2023 14:11
    Last modified:11 Nov 2024 13:49
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/84512
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