Breast cancer survival analysis with molecular subtypes : an initial step

Zhang, Lingli and Wu, Jiaiun and Zhao, Youbing and Hu, Wenxian and Qin, Aihong and Dong, Feng and Liu, Enjie and Zeng, Hao and Xie, Hao and Du, Hui; (2022) Breast cancer survival analysis with molecular subtypes : an initial step. In: 2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE). 2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE) . IEEE, TWN, pp. 363-366. ISBN 9781665484879 (https://doi.org/10.1109/bibe55377.2022.00081)

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Abstract

As a predominant threat to women's health world-wide, breast cancer has become increasingly important in on-cology research. The discovery of molecular subtypes of breast cancer has led to more subtype oriented treatment and prognosis prediction. Effective prognosis models help to estimate the recurrence as well as the quality and duration of survival, leading to more personalized treatments. However, most traditional prognostic models either ignore molecular subtypes or only make limited use of them. The roles of molecular subtypes in the development and treatment of breast cancer have not been fully revealed. With the over 1200 cases collected by Sir Run Run Shaw Hospital of Zhejiang University in the past two decades, we aim to improve understanding of molecular subtypes and their impacts on the prognosis via data analysis in the long run. As the initial stage, this short paper presents our preliminary work of logistic regression experiments with the data. Though molecular subtypes have not been included the tentative model, they are to be explored further in following stages.

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