Impact of the flavonoid quercetin on beta-amyloid aggregation revealed by intrinsic fluorescence

Alghamdi, Abeer and Birch, David J.S. and Vyshemirsky, Vladislav and Rolinski, Olaf J. (2022) Impact of the flavonoid quercetin on beta-amyloid aggregation revealed by intrinsic fluorescence. Journal of Physical Chemistry B, 126 (38). pp. 7229-7237. ISSN 1520-6106 (https://doi.org/10.1021/acs.jpcb.2c02763)

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Abstract

We report the effects of quercetin, a flavonoid present in the human diet, on early stage beta-amyloid (Aβ) aggregation, a seminal event in Alzheimer's disease. Molecular level changes in Aβ arrangements are monitored by time-resolved emission spectral (TRES) measurements of the fluorescence of Aβ's single tyrosine intrinsic fluorophore (Tyr). The results suggest that quercetin binds β-amyloid oligomers at early stages of their aggregation, which leads to the formation of modified oligomers and hinders the creation of β-sheet structures, potentially preventing the onset of Alzheimer's disease.

ORCID iDs

Alghamdi, Abeer, Birch, David J.S. ORCID logoORCID: https://orcid.org/0000-0001-6400-1270, Vyshemirsky, Vladislav and Rolinski, Olaf J. ORCID logoORCID: https://orcid.org/0000-0002-7838-779X;
CORE (COnnecting REpositories)